Op-brai130213 3151..3162

نویسندگان

  • Sarosh R. Irani
  • Charlotte J. Stagg
  • Jonathan M. Schott
  • Clive R. Rosenthal
  • Susanne A. Schneider
  • Philippa Pettingill
  • Rosemary Pettingill
  • Patrick Waters
  • Adam Thomas
  • Natalie L. Voets
  • Manuel J. Cardoso
  • David M. Cash
  • Emily N. Manning
  • Bethan Lang
  • Shelagh J. M. Smith
  • Angela Vincent
  • Michael R. Johnson
چکیده

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype Sarosh R. Irani, Charlotte J. Stagg, Jonathan M. Schott, Clive R. Rosenthal, Susanne A. Schneider, Philippa Pettingill, Rosemary Pettingill, Patrick Waters, Adam Thomas, Natalie L. Voets, Manuel J. Cardoso, David M. Cash, Emily N. Manning, Bethan Lang, Shelagh J. M. Smith, Angela Vincent and Michael R. Johnson

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Op-brai130213 1..12

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype Sarosh R. Irani, Charlotte J. Stagg, Jonathan M. Schott, Clive R. Rosenthal, Susanne A. Schneider, Philippa Pettingill, Rosemary Pettingill, Patrick Waters, Adam Thomas, Natalie L. Voets, Manuel J. Cardoso, David M. Cash, Emily N. Manning, Bethan La...

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Asthma is a common chronic respiratory disease. In a previous study, we found several circulating microRNA signatures associated with childhood asthma and selected miR-3162-3p for subsequent studies. Since the target proteins and underlying molecular mechanisms of miR-3162-3p in asthma etiopathogenesis are not well characterized, we designed this study to clarify its role. We employed bioinform...

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Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways

We hypothesize that miR-3151, localized to a GWAS-identified chronic lymphocytic leukemia (CLL) risk locus (8q22.3), is a tumor suppressor miRNA silenced by promoter DNA methylation in CLL. The promoter of miR-3151 was methylated in 5/7 (71%) CLL cell lines, 30/98 (31%) diagnostic primary samples, but not normal controls. Methylation of miR-3151 correlated inversely with expression. Treatment w...

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MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.

The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a top candidate for targeted treatment strategies in MM and PTC. We show that BRAF mutations in bot...

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The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied mi...

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تاریخ انتشار 2013